United States and its territories. Indications, uses and warnings on Drugs. Dose is based on body weight and must be determined by your doctor. Do not flush medications down the toilet or pour them into a drain unless instructed to do so. Properly discard this product when it is expired or no longer needed See How to Use section.
The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. Take exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. This medication may also be used to help protect the kidneys from harm due to diabetes. Marfan syndrome, Sjogren's syndrome, lupus, scleroderma, or rheumatoid arthritis.
This medicine may affect blood sugar levels. If you notice a change in the results of your blood or urine sugar tests, or if you have any questions, check with your doctor. In the long-term clinical trials, the following adverse reactions occurred in greater than or equal to 5% and are not listed in Table 1: diarrhea 10%; 8%; infection viral 6%; and 5%. Adrenocortical function monitoring may be required in these patients and the dose of corticosteroid treatment with high systemic effects should be reduced cautiously.
It is not intended as medical advice for individual conditions or treatment. It is not a substitute for a medical exam, nor does it replace the need for services provided by medical professionals. Talk to your doctor, nurse or pharmacist before taking any prescription or over the counter drugs including any herbal medicines or supplements or following any treatment or regimen. Only your doctor, nurse, or pharmacist can provide you with advice on what is safe and effective for you. Consider monitoring white blood cell counts periodically in patients with collagen vascular disease, especially if the disease is associated with impaired renal function.
Remove the protective liner and apply the patch to the skin area that is most painful. Apply the prescribed number of patches, usually only once a day for up to 12 hours or as directed by your doctor. Do not apply more than 3 patches once a day or leave any patch on for longer than 12 hours in any 24-hour period. If a smaller patch is needed, it may be cut with scissors before the liner is removed. Avoid getting the patch wet since it may not stick to the skin. At baseline, the median CDAI was 290. If you miss a dose, use it as soon as you remember. If it is near the time of the next dose, skip the missed dose and resume your usual dosing schedule. ENTOCORT EC 6 mg once daily. Food and Drug Administration. WebMD does not endorse any specific product, service or treatment. Read this Patient Information before you start taking ENTOCORT EC and each time you get a refill. There may be new information. This information does not take the place of talking to your healthcare provider about your medical condition or your treatment. Ask your doctor whether you will need to remove your patch before the test and apply a new patch afterward, and how to so properly. To reduce the risk of dizziness and lightheadedness, get up slowly when rising from a sitting or lying position. Check with your doctor right away if you become sick while taking this medicine, especially with severe or continuing nausea, vomiting, or diarrhea. These conditions may cause you to lose too much water or salt and may lead to low blood pressure. You can also lose water by sweating, so drink plenty of water during exercise or in hot weather. Safety and efficacy have not been established in patients younger than 18 years. Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. It is not known whether lisinopril passes into breast milk or if it could harm a nursing baby. Do not use this medication without telling your doctor if you are breast-feeding a baby. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist. One woman had been taking the medication for 10 years without a problem before a bite of an apple landed her in the hospital. Remember that your doctor has prescribed this because he or she has judged that the benefit to you is greater than the risk of side effects. Many people using this medication do not have serious side effects. Some medical conditions may interact with Prinivil.
Increased risk of infection. Check with your doctor right away if you have upper stomach pain, pale stools, dark urine, loss of appetite, nausea, unusual tiredness or weakness, or yellow eyes or skin. These could be symptoms of a serious liver problem. In vivo investigations with intravenous doses in healthy subjects were in agreement with the in vitro findings. Check with your pharmacist about how to dispose of unused medicine. If you need surgery, tell the surgeon ahead of time that you are using lisinopril. You may need to stop using the medicine for a short time. Diabetes patients - Prinivil may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine. What should I avoid while taking lisinopril Prinivil? Do not drink grapefruit juice during your treatment with ENTOCORT EC. Drinking grapefruit juice can increase the level of ENTOCORT EC in your blood. Take ENTOCORT EC capsules whole. Do not chew or crush ENTOCORT EC capsules before swallowing. Lisinopril may also be used for purposes not listed in this medication guide. The information contained in the Truven Health Micromedex products as delivered by Drugs. Use is not recommended. Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing. Use Prinivil with caution in the ELDERLY; they may be more sensitive to its effects. Budesonide is metabolized via CYP3A4. Potent inhibitors of CYP3A4 can increase the plasma concentrations of budesonide several-fold. Conversely, induction of CYP3A4 potentially could result in the lowering of budesonide plasma concentrations. Severe and sometimes fatal liver problems have happened with Prinivil. Discuss any questions or concerns with your doctor.
Patent and Trademark Office and assigns exclusive legal right to the patent holder to protect the proprietary chemical formulation. The patent assigns exclusive legal right to the inventor or patent holder, and may include entities such as the drug brand name, trademark, product dosage form, ingredient formulation, or manufacturing process A patent usually expires 20 years from the date of filing, but can be variable based on many factors, including development of new formulations of the original chemical, and patent infringement litigation. Prinivil may not work as well in black patients. Contact your doctor if your symptoms do not improve or if they become worse. May increase dose every 2 to 3 weeks. Clinical studies of ENTOCORT EC did not include sufficient numbers of patients aged 65 and over to determine whether they respond differently from younger patients. Of the 651 patients treated with ENTOCORT EC in clinical studies, 17 3% were greater than or equal to 65 years of age and none were greater than 74 years of age. Other reported clinical experience has not identified differences in responses between the elderly and younger patients. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. Using this medicine with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines. Lisinopril is used to treat high blood pressure. Lowering high blood pressure helps prevent strokes, heart attacks, and kidney problems. It is also used to treat heart failure and to improve survival after a heart attack. While wearing your patch, avoid exposing it to direct heat sources such as heating pads, electric blankets, heat lamps, saunas, hot tubs, heated waterbeds, or prolonged direct sunlight. Heat may cause more drug to be released into your body, increasing the chance of side effects. Additionally, TRUVEN HEALTH MAKES NO REPRESENTATION OR WARRANTIES AS TO THE OPINIONS OR OTHER SERVICE OR DATA YOU MAY ACCESS, DOWNLOAD OR USE AS A RESULT OF USE OF THE THOMSON REUTERS HEALTHCARE PRODUCTS. ALL IMPLIED WARRANTIES OF MERCHANTABILITY AND FITNESS FOR A PARTICULAR PURPOSE OR USE ARE HEREBY EXCLUDED. Truven Health does not assume any responsibility or risk for your use of the Truven Health products. May increase risk of this condition occurring again. In Canada - Call your doctor for medical advice about side effects. You may report side effects to Health Canada at 1-866-234-2345. To reduce your risk of side effects, your doctor may direct you to start this medication at a low dose and gradually increase your dose. Follow your doctor's instructions carefully. PREGNANCY AND BREAST-FEEDING: Prinivil may cause birth defects or fetal death if you take it while you are pregnant. If you think you may be pregnant, contact your doctor right away. It is not known if this medicine is found in breast milk. Do not breast-feed while taking Prinivil. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. Drugs.
Store Prinivil at room temperature, between 68 and 77 degrees F 20 and 25 degrees C. Do not freeze. Store away from heat, moisture, and light. Do not store in the bathroom. Keep Prinivil out of the reach of children and away from pets. Prinivil may cause a serious side effect called angioedema. The risk may be higher in black patients. Contact your doctor at once if you develop swelling of the hands, face, lips, eyes, throat, or tongue; difficulty swallowing or breathing; or hoarseness. Keep ENTOCORT EC and all medicines out of the reach of children. In a study in 11 healthy subjects, performed in a double-blind, randomized, placebo controlled manner, the effect of 5 to 6 days treatment with omeprazole 20 mg once daily on the pharmacokinetics of budesonide administered as ENTOCORT EC 9 mg as a single dose was investigated. Omeprazole 20 mg once daily did not affect the absorption or pharmacokinetics of budesonide. Tell your doctor if you develop any new symptoms. Where can I get more information? Treating high blood pressure alone or with other medicines. It is used along with other medicines to manage heart failure or improve survival after a heart attack. It may also be used for other conditions as determined by your doctor. Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention. Corticosteroids should be used with caution, if at all, in patients with active or infection, untreated fungal, bacterial, systemic viral or infections, or simplex. Too much sweating, diarrhea, or vomiting may cause loss of too much body water dehydration and increase your risk of lightheadedness. Report prolonged diarrhea or vomiting to your doctor. Be sure to drink enough fluids to prevent dehydration unless your doctor directs you otherwise. How should I take lisinopril Prinivil? In an open, non-randomized, cross-over study, 6 healthy subjects were given budesonide 10 mg as a single dose, either alone or concomitantly with the last ketoconazole dose of 3 days treatment with ketoconazole 100 mg twice daily. Check your blood pressure and pulse heart rate regularly while taking this medication. Learn how to check your own blood pressure and pulse at home, and share the results with your doctor. Lisinopril may rarely cause serious possibly fatal liver problems. Assuming the coefficient of extrapolation between the inhaled and oral doses is constant across all dose levels, at therapeutic doses of ENTOCORT EC, budesonide exposure to the nursing child may be up to 10 times higher than that by budesonide inhalation.
Keep container tightly closed. Do not use a household spoon because you may not get the correct dose. Advise Patients to read the FDA-Approved patient labeling Patient Information. Carcinogenicity studies with budesonide were conducted in rats and mice. Ask your healthcare professional how you should dispose of any medicine you do not use. Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. Contact your doctor or health care provider right away if any of these apply to you. The most common side effects of ENTOCORT EC in children 8 to 17 years of age, who weigh more than 55 pounds 25 kg are similar to the most common side effects in adults. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. Always consult your doctor or healthcare specialist for medical advice. Do not use this medication if you are allergic to lisinopril or to any other ACE inhibitor, such as benazepril Lotensin captopril Capoten fosinopril Monopril enalapril Vasotec moexipril Univasc perindopril Aceon quinapril Accupril ramipril Altace or trandolapril Mavik. Repeated 8 week courses of ENTOCORT EC can be given for recurring episodes of active disease. Budesonide is a substrate for CYP3A4. Avoid use with CYP3A4 inhibitors. Concomitant oral administration of a strong CYP3A4 inhibitor ketoconazole caused an eight-fold increase of the systemic exposure to oral budesonide.
The efficacy of ENTOCORT EC for maintenance of clinical were evaluated in four double-blind, placebo-controlled, 12-month trials in which 380 patients were randomized and treated once daily with 3 mg or 6 mg ENTOCORT EC or placebo. Patients ranged in age from 18 to 73 mean 37 years. Sixty percent of the patients were female and 99% were Caucasian. The mean CDAI at entry was 96. Among the four clinical trials, approximately 75% of the patients enrolled had exclusively ileal disease. was not performed following treatment. ENTOCORT EC 6 mg per day prolonged the time to relapse, defined as an increase in CDAI of at least 60 units to a total score greater than 150 or withdrawal due to disease deterioration. The median time to relapse in the pooled population of the 4 studies was 154 days for patients taking placebo, and 268 days for patients taking ENTOCORT EC 6 mg per day. ENTOCORT EC 6 mg per day reduced the proportion of patients with loss of symptom control relative to placebo in the pooled population for the 4 studies at 3 months 28% versus 45% for placebo. ENTOCORT EC with no reported episodes of adrenal insufficiency. Since prednisolone should not be stopped abruptly, tapering should begin concomitantly with initiating ENTOCORT EC treatment. Tell your healthcare provider if you have any side effect that bothers you or that does not go away. What happens if I overdose Prinivil? Measure the oral liquid correctly using the marked measuring spoon that comes with the package. Rinse the dosing spoon with water after each use. Millions of people take lisinopril. It was among the top five most commonly prescribed in the United States in 2011, according to the market research firm IMS Health. If exposed, therapy with zoster immune globulin VZIG or pooled IVIG as appropriate, may be indicated. If exposed to measles, with pooled may be indicated. See prescribing information for VZIG and IG. If chicken pox develops, treatment with agents may be considered.
If contact with the accidentally occurs, wash your right away with water and protect them until normal feeling returns. Lisinopril is used to treat high blood pressure hypertension congestive heart failure, and to improve survival after a heart attack. Do not share this medication with others. Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. Following administration of ENTOCORT EC, the time to peak concentration varied in individual patients between 30 and 600 minutes. Mean oral bioavailability of budesonide ranged from 9% to 21% both in patients and in healthy subjects, demonstrating a high first-pass elimination of the drug. Adrenal suppression. When ENTOCORT EC is taken for a long period of time chronic use adrenal suppression can happen. This is a condition in which the adrenal glands do not make enough hormones. Before having surgery, tell your doctor or dentist about all the products you use including prescription drugs, nonprescription drugs, and herbal products. Therapeutic Equivalence-Related Terms, Pharmaceutical Equivalents generally will be coded AB if a study is submitted demonstrating bioequivalence.
This section provides information on the proper use of a number of products that contain lisinopril. It may not be specific to Prinivil. Please read with care. At baseline, the median CDAI was 277. Advise patients to immediately report any signs or symptoms of angioedema breathing difficulty or swelling of face, eyes, lips, or tongue and to stop taking this drug until consulting a physician. Prinivil is to be used only by the patient for whom it is prescribed. Do not share it with other people. Three-character codes are assigned only in situations when more than one reference listed drug of the same strength has been designated under the same heading. Two or more reference listed drugs are generally selected only when there are at least two potential reference drug products which are not bioequivalent to each other. If a study is submitted that demonstrates bioequivalence to a specific listed drug product, the generic product will be given the same three-character code as the reference listed drug it was compared against. What should I discuss with my healthcare provider before taking lisinopril Prinivil? The use of the Truven Health products is at your sole risk. These products are provided "AS IS" and "as available" for use, without warranties of any kind, either express or implied. Truven Health and Drugs. When corticosteroids are used chronically, systemic effects such as hypercorticism and adrenal suppression may occur. Exclusivity is the sole marketing rights granted by the FDA to a manufacturer upon the approval of a drug and may run simultaneously with a patent. Exclusivity periods can run from 180 days to seven years depending upon the circumstance of the exclusivity grant. OTHER USES: This section contains uses of this drug that are not listed in the approved professional labeling for the drug but that may be prescribed by your health care professional. Use this drug for a condition that is listed in this section only if it has been so prescribed by your health care professional. Drug interactions may change how your medications work or increase your risk for serious side effects. This document does not contain all possible drug interactions.
FDA product labels and may differ in countries outside the USA. Every effort has been made to ensure that the information provided on this page is accurate, up-to-date and complete, but no guarantee is made to that effect. Drugs. Avoid ingestion of grapefruit juice with budesonide. FRIDAY, Nov. 8 HealthDay News -- Doctors are warning people who take certain drugs for to watch out for a rare but sometimes serious side effect. Make sure any doctor or dentist who treats you knows that you are using this medicine. You may need to stop using this medicine several days before having surgery. Hyperkalemia high potassium in the blood may occur while you are using this medicine. Check with your doctor right away if you have the following symptoms: abdominal or stomach pain, confusion, difficulty with breathing, irregular heartbeat, nausea or vomiting, nervousness, numbness or tingling in the hands, feet, or lips, shortness of breath, or weakness or heaviness of the legs. Do not use supplements or salt substitutes containing potassium without first checking with your doctor. AUC in healthy subjects. Increased risk of potassium levels in the body becoming too high. Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of a drug cannot be directly compared to rates in the clinical trials of another drug and may not reflect the rates observed in practice. ENTOCORT EC 9 mg once daily for 7 days. In patients who have not had these diseases, particular care should be taken to avoid exposure. Occurring in greater than or equal to 5% of the patients in any treated group. The presence of other medical problems may affect the use of this medicine. For the treatment of high blood pressure, it may take 2 to 4 weeks before you get the full benefit of this medication. For the treatment of heart failure, it may take weeks to months before you get the full benefit of this medication. Tell your doctor if your condition does not get better or if it gets worse for example, your blood pressure readings remain high or increase. Budesonide plasma concentrations were not detected and no adverse events were noted in the breastfed infants following maternal use of inhaled budesonide. The recommended daily dose of ENTOCORT EC capsules is higher up to 9 mg daily compared with inhaled budesonide up to 800 mcg daily given to mothers in the above described study. These findings occurred in the presence of maternal toxicity.
Advise patients to avoid exposure to people with chicken pox or measles and, if exposed, to consult their healthcare provider immediately. Products meeting necessary bioequivalence requirements. Females of childbearing age should be informed of the consequences of exposure to this drug during pregnancy; ask these patients to report pregnancies as soon as possible. Lactation studies have not been conducted with oral budesonide, including ENTOCORT EC, and no information is available on the effects of the drug on the breastfed infant or the effects of the drug on milk production. Budesonide is provided as a mixture of two epimers 22R and 22S. The empirical formula of budesonide is C 25H 34O 6 and its molecular weight is 430. Store the mixed oral liquid at or below room temperature for up to 4 weeks. All medicines may cause side effects, but many people have no, or minor, side effects.
Store at room temperature away from light and moisture. not store in the bathroom. Keep the patch sealed in its protective envelope until ready to use. Keep all away from children and pets. Disclaimer: The indications, uses and warnings for individual medications outside the USA are determined by local regulatory bodies in each country or region. The Drugs. Dizziness, lightheadedness, tiredness, or headache may occur as your body adjusts to the medication. Dry cough may also occur. If any of these effects last or get worse, tell your doctor or pharmacist promptly. Using this medicine with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take. Keep out of the reach of children. Following absorption, budesonide is subject to high first pass 80% to 90%. In vitro experiments in human liver microsomes demonstrated that budesonide is rapidly and extensively biotransformed, mainly by CYP3A4, to its 2 major metabolites, 6β-hydroxy budesonide and 16α-hydroxy prednisolone. Use and dose must be determined by your doctor.
prinivil otc online, money order now prinivil uk, generic prinivil cvs, buy prinivil pills, alternative to prinivil, vendita prinivil, order prinivil payment otc, buy prinivil germany, buy now prinivil online usa, buy prinivil for, prinivil cost ireland, canada prinivil usage, brand prinivil buy online, cheap legal prinivil for sale, prinivil can i buy online, order now online prinivil pills, purchase now cheap prinivil canada, buy prinivil england, average prinivil 100 mg, prinivil online mexico, buy cheap prinivil pharmacy uk, prinivil can i buy shop, generic or brand prinivil, buy now online prinivil payment, prinivil online price, cheap prinivil order mastercard canada, cheap prinivil level, guardian pharmacy prinivil, shop prinivil basket, buy prinivil turkey, purchase now cheap prinivil visa, prinivil high street, cheapest prinivil order shop canada, cheapest prinivil purchase online europe, buy now prinivil pharmacy uk, buy prinivil online south africa, prinivil buy now online uk, prinivil generic replacement, cheap prinivil mexico, prinivil where to buy payment, cheapest prinivil order online uk, order generic prinivil shopping usa, buy prinivil pills online shop, pharmacy in cozumel prinivil 2016, buy prinivil online quick delivery, prinivil purchase store, price prinivil vomiting, cheap prinivil buy now uk, purchase prinivil no rx needed, discount card for prinivil, street prinivil 500 mg, cheaper than prinivil, buy cheap prinivil shopping usa, generic prinivil no doctor prescriptions, purchase prinivil 400 mg, how much does prinivil pharmacy, order prinivil online visa canada, buy prinivil online cheap australia, buy prinivil vancouver bc, prinivil online mastercard money order, cost prinivil medicamento, purchase prinivil with mastercard, cheap prinivil medication, buy online prinivil store, generic prinivil order shopping canada, buy prinivil 25 mg, prinivil order online payment canada, prinivils in the philippines, prinivil online safe, prinivil buy online cheap, order prinivil malarone, get prinivil, order generic prinivil mastercard australia, money order prinivil payment canada, cost of prinivil 5mg, prinivil purchase uk, cost of prinivil 500 mg, pharmacy available prinivil, canadian prinivil prescription, order cheap prinivil pharmacy canada, can you prinivil answers, buying prinivil online safe, buy prinivil nottingham, prinivil brand price, prinivil generic reviews, prinivil online best price, how much does prinivil cost at walgreens, cost of prinivil in singapore, buy prinivil sydney, prinivil no physician, store prinivil price, can i purchase now prinivil, canada shipping prinivil, canada prinivil do, brand prinivil qt, where can u buy prinivil in canada, cost prinivil dose, pharmacy prinivil malaysia, generic prinivil gunstig, prinivil how to purchase otc, pharmacy prinivil tablet, purchase prinivil benefits, prinivil buy online europe, order generic prinivil online australia, order prinivil payment australia, prinivil price walgreen, prinivil omni, buy prinivil vancouver bc, purchase prinivil, mail order cheapest prinivil australia
Advise patients against using potassium-sparing diuretics, potassium supplements or potassium-containing salt substitutes without consulting their physician. Two placebo-controlled clinical trials Studies 2 and 3 were conducted. In cases presented at the annual meeting of the American College of Allergy, and Immunology this week in Baltimore, doctors recount how two patients experienced sudden and swelling of the lips, and throat after eating fruit. WebMD User Reviews should not be considered as medical advice and are not a substitute for professional medical advice, diagnosis, or treatment. Never delay or disregard seeking professional medical advice from your physician or other qualified healthcare provider because of something you have read on WebMD. You should always speak with your doctor before you start, stop, or change any prescribed part of your care plan or treatment. WebMD understands that reading individual, real-life experiences may be a helpful health information resource but they are never a substitute for professional medical advice from a qualified healthcare provider.
ENTOCORT EC capsules and prednisolone in a in healthy volunteers. The mean decrease in the area under the plasma cortisol concentration-time curve over 24 hour AUC 0-24 was greater 78% with prednisolone 20 mg per day compared to 45% with ENTOCORT EC 9 mg per day. Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. ENTOCORT EC and other medicines may affect each other causing side effects. CYP3A4 substrate. The effect of budesonide 9 mg once daily on the plasma concentrations of ethinyl estradiol was not studied.
Your doctor may occasionally change your dose to make sure you get the best results. ENTOCORT EC may harm your unborn baby. Talk to your healthcare provider about the possible risk to your unborn baby if you take ENTOCORT EC when you are pregnant. It is not known if ENTOCORT EC passes into your breast milk or if it will affect your baby. Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.
ENTOCORT EC in adults, and by safety and pharmacokinetic studies performed in pediatric patients. Medicines are sometimes prescribed for purposes other than those listed in a Patient Information leaflet. Do not use ENTOCORT EC for a condition for which it was not prescribed. Do not give ENTOCORT EC to other people, even if they have the same symptoms you have. It may harm them. You can ask your healthcare provider or pharmacist for information about ENTOCORT EC that is written for health professionals. These plasma clearance values approached the estimated liver blood flow, and, accordingly, suggest that budesonide is a high hepatic clearance drug.